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a somewhat different approach, their commonalities are notable and together comprise the humanistic school. These commonalities include the commitment to the phenomenological model that emphasizes that humans are able to be consciously reflective and have the ability to experience self-determination and freedom. Thus, therapists must be able to fully understand a person s perception of internal and external reality in order to not only better understand their feelings and behavior but also offer assistance. Another commonality included the notion that humans strive toward growth and are not, for example, trying to maintain homeostasis by satisfying various primitive needs and conflicts. The humanistic approach also championed a belief in free will and regarded human behavior as not just a by-product of early childhood experiences or merely conditioned responses to the external environment. Finally, the humanistic approach is person-centered with maximum respect for the individual and his or her experiences (Tageson, 1982). The client-centered and phenomenological approach of Carl Rogers became the most influential humanistic therapy. While Rogers was trained in the more traditional psychodynamic approach, he rejected it to provide a compelling alternative with the clientcentered approach. The approach emphasizes therapist empathy, unconditional positive regard, congruence, intensive active listening, and support to help individuals and groups reach their full human potential (Rogers, 1951, 1954, 1961). Rogers felt that humans naturally strive toward their potential and that psychotherapy was a catalyst that could assist them in this endeavor.

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progenitors of broblastic, reticular, adipogenic, osteogenic, and possibly other cells. Our vision of the lineage pathways available to mesenchymal stem cells was originally depicted in the mesengenic process diagram seen in Fig. 2.1. In this scheme, the pathways are arranged so that the best-understood are on the left, and the least established are on the right [Caplan, 1994]. Our laboratory s interest in marrow-derived mesenchymal stem cells (MSCs) can be viewed as a logical consequence of our earlier in vitro studies involving mesenchymal cells of the embryonic chick limb bud system [Caplan, 1977, 1984]. Although there are obvious differences between the two systems, there are also certain parallels between the limb bud and marrow stromal systems. Most importantly, both bone and cartilage development in the embryonic limb bud and bone turnover and repair in the adult limb result from the division of small numbers of progenitor cells (MSCs) and the ultimate commitment and differentiation of the progeny of these cells [Caplan, 1991; Bruder et al., 1994]. Thus Ohgushi et al. [1989, 1990] demonstrated that intact or disaggregated rat marrow forms bone and cartilage when loaded into porous ceramic (hydroxyapatite-tricalcium phosphate) cubes and implanted into subcutaneous sites in syngeneic hosts. Goshima et al. [1991a] achieved similar results when they loaded the same type of ceramics with cultured rat marrow cells, referred to as mesenchymal stem cells. An important development occurred when Haynesworth et al. [1992b] demonstrated that cultured human marrow MSCs also generate bone, but rarely cartilage, when introduced into the same assay system. Interestingly, companion human cells loaded into diffusion chambers did not form bone; accordingly, we consider the

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personality have been concerned with reducing the covariance between lower-order traits to fewer factors. Residual variance speci c to each trait is neglected. Biometric path models applied to twin data decompose this variance into etiological components. This makes it possible to evaluate the signi cance of these speci c traits. These models offer the opportunity to evaluate the hierarchical structure of personality by comparing the t of the two models to the same data set. The common pathways model is the biometric equivalent to the traditional model of exploratory factor analysis used to delineate the phenotypic structure of traits. As applied to each of the ve-factor domains, the model postulates a single latent factor for each domain that mediates the effects of genetic and environmental effects on each lower-order trait. In the case of NEO-PI-R Neuroticism, a latent variable of neuroticism is hypothesized through which genetic and environmental factors in uence the six facets of Anxiety, Hostility, Depression, SelfConsciousness, Impulsivity, and Vulnerability. In contrast, the independent pathways model postulates direct genetic and environmental effects on each facet trait. The ts of these models provide an opportunity to evaluate different conceptions of personality structure. If the common pathways model provides the best t, the implication is that the hierarchical structure of personality arises from the effects of higher-order factors that have a genetic and environmental basis. The task is then to explain how this entity differs from lower-order or facet traits and the role it plays in the formation of the