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The level of nancing in biotech is a re ection of the prospect for gain, the domestic and global nancial conditions, and a country s commitment to technology development A commonly used metric for gauging this com mitment is the amount of money a country spends on research and devel opment relative to its gross domestic product (GDP) The greater the R&D to GDP ratio, the more likely the industries in the country will have innovative products in the future In addition, this ratio re ects the struc ture of industrial activity, in that economies with an emphasis on manu facturing tend to be more R&D-oriented than economies based on services or agriculture As a point of reference, consider that overall research and develop ment expenditure in the EU represented 19 percent of its gross domestic product in 2000 This compares to 2.

Assets are things of value that your company owns. QuickBooks distinguishes between two types of assets: current assets and xed assets. Current assets include cash accounts and assets that you could convert to cash within one year. Inventory items that you hold for sale to customers are an example of current assets. Your accounts receivable, which is the money that customers owe to you, is another example of a current asset.

+ C.c. )

(6.93)

~ [ ~ + e-~aI2 eigtlal exp (laI2eigt/lal) + c.c'] .

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Fixed assets are assets that you won t convert to cash within the year. Examples of xed assets are equipment, machinery, trucks, desks, and cash registers. Fixed assets are often depreciated, which means that the business will spread the cost of the asset over a number of years or accounting periods. Depreciation is the accounting method used to offset a portion of the original cost of the asset against a business s income each year. For example, if I purchase a $10,000 photocopy machine that makes collated, stapled, and scented copies of all of my legal documents, I might depreciate that asset, or write it off over a ve-year period. This method would assume that at the end of ve years, the machine will have no value because it is worn out or obsolete. To determine the value of an asset at any time during its useful life, you would subtract the amount in the accumulated depreciation account from the original cost. In other words, depreciation is an expense that does not reduce the balance in any cash account. Instead, it reduces the value of the xed asset being depreciated. Take a look at how this works. Figure 4-4 shows how a partially depreciated truck is represented on Larry s Landscaping s Balance Sheet.

69 percent for the United States, 298 percent for Japan, and 337 percent for Finland The United States has traditionally lagged behind Sweden, Japan, Finland, and Switzer land in the ratio of R&D spending to GDP Even though several coun tries spend more on research and development relative to their GDP, the United States spends more in absolute terms, because of the size of its economy When it comes to assessing the impact of overall research and develop ment to the biotech industry, it s dif cult to disregard activity in areas not speci cally categorized as biotech For example, research and development activities in Internet-related businesses, communications, and general com puting are likely to have an enabling effect on biotech research and devel opment.

. t 2t igt/lal '" 1 ~ _ ___ g e '" + lal 21a12' 2

I, we can expand the exponential in (6.93): (6.94)

Figure 4-4: Larry s Landscaping s Balance Sheet shows the original cost of a xed asset, a truck, offset by the amount of accumulated depreciation.

Then equation (6.93) becomes [130] Pll (t)

Furthermore, even if a strict de nition of what constitutes biotech research and development is adopted, pharmaceutical research and devel opment accounted for almost half of R&D expenditure in the United States in 2000, according to Organization for Economic Cooperation and Development (OECD) The R&D to GDP ratio uctuates over time as a function of the strength of the economy and changing priorities in government nancing As shown in Figure 68, this ratio consistently increased in the 1980s and 1990s for Japan and Canada, but uctuated considerably in most other G 8 countries (Japan, Germany, France, Canada, Russia, Italy, the United States, and the United Kingdom) The exception is the United Kingdom, which showed a consistently negative trend, with a ratio of 238 in 1982 and 186 in 2000, according to National Science Foundation, Science and.

(1 + e-g2t2/2 cos 2gtlal) .

Liability accounts re ect your company s debts what is owed to others. Similar to assets, liabilities are categorized as current or long-term. Current

(6.95)

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