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Autoantibodies have been found that are directed against myelin oligodendrocyte glycoprotein (MOG) and myelin basic protein (MBP) It has also been demonstrated that subsets of T cells (CD41 Th2 cells) are activated by MBP and MOG to activate B cells, the production of oligoclonal bands and membrane attack complexes, and the release of cytokines [tumor necrosis factor alpha (TNF- ), interleukins, interferon gamma (IFN- )] The in ammatory process erodes the blood-brain barrier and ultimately destroys both oligodendroglia and axons The eventual functional outcome re ects both the activity of this in ammatory cascade and the degree of axonal damage In other cases, there may be a compromise of oligodendroglial function and axonal degeneration in the absence of prominent in ammation (see reviews by French-Constant and Hemmer) Nevertheless, most immunologists currently subscribe to the notion that MS is mediated by a T-cell sensitization to myelin.

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This idea is supported by numerous lines of evidence including the observation that T cells initiate the lesions of experimental allergic encephalomyelitis (EAE), which is assumed to be an animal model of MS, as suggested by Adams Although the entry of autoreactive T cells into the CNS results in a perivascular in ammatory reaction, its relationship to MS is unclear Conceivably, intense T-cell stimulation is in itself suf cient to induce demyelination, but it is also possible that the primary target of the immune reaction is the myelin sheath or some component thereof and that the T-cell in ltration is the result of the demyelination Other investigators believe that an additional insult is required, as illustrated by the EAE animal model, in which myelin alone is not a suf cient factor but always requires an adjuvant immune stimulus.

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EAE is clearly an imperfect model; it is not a naturally occurring disease but one in which a demyelination of the CNS is induced in susceptible animals in a single episode by autologous myelin antigens The.

for 17 is devoted to the most common approaches numerical integration-the function Theserelationships basedon replacinga complicated are Newton-Cotes formulas. tabulateddata with a simple polynomial that is easy to integrate.Three of the most or formulasarediscussed detail: the trapezoidalrule, Simpson's in widely usedNewton-Cotes wherethe data rule. All theseformulasare designed cases for 1l3 rule, andSimpson's318 integratedis evenly spaced.In addition, we also include a discussionof numerical to be

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the other wire of the primary goes to another output. You might think that this odd circuit may seem like it does nothing, since no current is flowing in the open circuit, and you would be correct. If you take each output terminal (one in each hand) and connect them together to close the circuit, the primary winding will be energized, but still nothing happens at this exact point. It s when you disconnect the two terminals that things become interesting a nice snapping sound and a good shock will flow through your body. When you open the circuit, the energy stored in the electromagnet collapses back through the now open circuit and sends a high-voltage induction into your fingers. So simple, yet so effective! Figure 7-7 shows the simple wiring needed to connect the battery to the primary coil as indicated in the schematic diagram. The unused transformer wires should be taped off, but feel free to play around with the other wires to see how the shock effect is different. You will likely find that the primary windings will offer the greatest shock, whereas the secondary windings will make a louder spark, but with much less shock factor. Now, once again you are faced with some creative thinking tasks in order to disguise your device in order to deliver it to your rightly suspicious friends effectively. This project lends itself to hundreds of cool designs, since the

Figure 4-3

First, consider driving north as positive mileage and driving south as negative mileage. Then you drive the following distances in miles, and in this order: 25, 45, 50, 7, 12, 49, 5 Add these all up: 25 + ( 45) + 50 + ( 7) + 12 + ( 49) + ( 5) = 19 That s 19 miles south of your home town. Now imagine that driving south is positive mileage and driving north is negative mileage. Then you your trip is a sum of displacements like this: 25 + 45 + ( 50) + 7 + ( 12) + 49 + 5 = 19 Again, that s 19 miles south.

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PRO POINTER In general, native plants typically require less fertilizer, less maintenance, and fewer pesticides. Any building uses up natural space. This affects birds, animals, insects, and other natural creatures. It is only fair to give these affected species a natural landscape to come to as an oasis in a sea of pavement.

Solder comes in gauges like wire. The two most common types of solder, are 18 ga., used for general work, and the thinner 22 ga., used for fine work on printed circuit boards.

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